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Smoothened and Patched and Sonic Hedgehogs – From Cyclopic Sheep to Targeted...
by: Simon Madorsky, MD & Cole Fulwider, MD What does Frizzled, Frazzled, Dishevelled, and Smoothened have to do with the Sonic Hedgehog? These are some of the humorously named genes in Drosophila...
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Vismodegib – A Breakthrough in Basal Cell Carcinoma Treatment
Vismodegib, a Hedgehog Pathway Inhibitor, has been recently shown to be highly effective for advanced basal cell carcinoma in Phase II clinical studies. Discovery of the Hedgehog Signaling Pathway is...
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Erivedge (Vismodegib) – The Unconsummated Miracle
Erivedge (vismodegib) is the new orally administered hedgehog-pathway inhibitor. Its results in Basal Cell Nevus Syndrome (Gorlin syndrome) are impressive as shown by Tang, Mackay, Aszterbaum et al in...
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